Graduating with a degree in mathematics in 1910, Razmadze taught mathematics in secondary schools while he continued to work for his Master's degree. He was awarded this degree in 1917, taught at Moscow University for a few months, then returned to Georgia near the end of the year 1917.
Razmadze was one of the founders of Tbilisi University and he taught at this university from the time that it opened in 1918. He held a chair in the Physics and Mathematics Faculty in Tbilisi for the rest of his life. Chrelashvili describes some of his work and achievements there in :-
As one of the founders of Tbilisi University, he (jointly with N I Muskhelishvili) directed the training of specialists in mathematics at the university. As a result, within a short period of time all the higher educational establishments of Georgia were supplied with teaching and scientific personnel in mathematics. Mathematics teachers for most secondary schools of Georgia were also trained here.Razmadze wrote the first textbooks in Georgian on analysis and integral calculus. In  Razmadze's Introduction to differential calculus a little-known textbook published in Russian in 1923 is described.
His work was on the calculus of variations, continuing work by Weierstrass and Hilbert. The fundamental lemma of the calculus of variations is named after him. He also did important work on discontinuous solutions. Yushkevich writes :-
[Razmadze] presented a report on his research to the International Congress of Mathematicians at Toronto in 1924, and for that paper he received the doctorate in mathematics from the Sorbonne.Chrelashvili also notes in  how Razmadze's work had been recognised by the international mathematical community. He writes that:-
Following Razmadze's death ..., the outstanding French mathematician Jacques Hadamard sent a telegram of condolence to Tbilisi University, saying that he, together with all the mathematicians of France and the world, was profoundly grieved at the death of Razmadze. This is undoubtedly another expression of the international recognition of Razmadze's scientific contribution and his talent.
Article by: J J O'Connor and E F Robertson